In a large bowl mix garlic powder, onion powder, egg, breadcrumbs, salt, and pepper until combined.
Preheat oven to 375 F.
Add pork and beef, mix to combine (for better results, try mixing with your hands).
Prepare a small bowl with warm water to dip your hands in. Roll the mixture between your hands into medium-sized balls, dipping your hand in water after each meatball. You should end up with 24 or if rolled into smaller balls, about 28 meatballs.
Transfer to a baking sheet lined with parchment paper or foil, and bake for 25 minutes.
Meanwhile, prepare the marinara sauce by combining all the ingredients in a large pan over low-medium heat. Let simmer for 5-10 minutes.
When meatballs are done, add them to the marinara sauce and let simmer over low0medium heat for 1 hour. Serve over pasta or rice and your favorite side salads.